Acyl Halides
Medchemexpress LLC (2e)-1-(3,4-dimethoxyphenyl)-5-fluoro-3-(4-fluorophenyl)-2-(2-fluorophenyl)pent-1-en-4-one bromide | 1390654-28-0 | >98.8% | 524.38 | 100 MG
KRN2 bromide is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. It selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hindering high-salt-induced NFAT5 and its target gene expressions. KRN2 also dose-dependently inhibits NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site of Nfat5 exon 1.
- Effectively suppresses AIA in which innate immune cells play a predominant role.
- Effectively suppresses CIA as well as AIA in mice.
- Decreases the production of pro-inflammatory cytokines and autoantibodies.
- Reduces macrophage infiltration.
Medchemexpress LLC Azido-choline bromide | 2059973-54-3 | 99.6% | 239.11 g·mol⁻¹ | C6H15BrN4O | 1 ML
N3-Cho bromide (azido-choline bromide) is an azide-bearing choline analogue supplied as a ready-to-use 10 mM solution in DMSO for bioorthogonal labeling and click chemistry applications. It is intended for incorporation into membrane mimetics and for use in azide-alkyne cycloaddition workflows.
- Contains an azide functional group compatible with click chemistry reactions.
- Supplied as a 10 mM solution in DMSO, ready for dilution or reaction.
- High purity (listed at 99.63%), suitable for research use.
- Soluble in DMSO and water.
- Stable in solution when sealed at -80°C (up to 6 months) or -20°C (up to 1 month).
- Useful for membrane labeling and synthesis of phospholipid head-group analogues.
Medchemexpress LLC Cetrimonium bromide-d42 | 907216-28-8 | 99.8% | 406.71 | C19D42BrN | 10 MG
Deuterium-labeled cetrimonium bromide (d42) is a stable isotope-labeled form of the cationic surfactant cetrimonium bromide, supplied for research use as a tracer or internal standard. It is provided as a powder at high purity with defined storage conditions.
- Deuterium labeled (d42) tracer/internal standard.
- Purity 99.8%.
- Molecular formula C19D42BrN; molecular weight 406.71.
- CAS number 907216-28-8.
- Supplied as a powder in small pack sizes (5 mg, 10 mg, 25 mg; larger sizes by inquiry).
- Storage: powder -20°C (3 years); in solvent -80°C (6 months), -20°C (1 month).
Medchemexpress LLC QX-314 (bromide) | 24003-58-5 | MFCD00083182 | 96.6% | 343.30 | C16H27BrN2O | 1 ML
QX-314 bromide is a membrane-impermeable, permanently charged sodium channel blocker provided as a ready-to-use 10 mM solution in DMSO or as a solid for reconstitution. It is commonly used in electrophysiology and neurophysiology experiments to selectively block intracellular voltage-gated sodium channels during recordings and manipulations.
- Membrane-impermeable quaternary lidocaine derivative.
- Available as 10 mM solution in DMSO or solid for reconstitution.
- Used to block intracellular voltage-gated sodium channels in electrophysiology.
- CAS number 24003-58-5 for unambiguous identification.
- Supplied with reported purity suitable for research applications.
Medchemexpress LLC Bromoacetyl-PEG3-DBCO | 00-00-0 | 98.6% | 600.50 | C29H34BrN3O6 | 5 MG
Bromoacetyl-PEG3-DBCO is a heterobifunctional PEG-based linker for bioconjugation and PROTAC synthesis. It combines a DBCO bioorthogonal handle with a bromoacetyl electrophile and a short PEG3 spacer to enable efficient, selective conjugation and good solubility in small-scale synthetic workflows.
- Contains a DBCO moiety for strain-promoted alkyne-azide cycloaddition (SPAAC).
- Provides a bromoacetyl reactive handle for selective conjugation to thiols.
- PEG3 spacer enhances solubility and flexibility in conjugates.
- High purity (~98.6%) suitable for synthetic applications.
- Oil appearance facilitates handling for small-scale synthesis.
- Recommended storage at -20°C in pure form for long-term stability.
- Available in milligram-scale quantities for research use.
Apexbio Technology LLC Tiotropium Bromide hydrate 139404-48-1 10mg
Tiotropium Bromide hydrate is a small-molecule antagonist targeting muscarinic acetylcholine receptors (mAChRs) It is designed to competitively inhibit mAChRs thereby modulating airway smooth muscle contraction and mediating bronchodilation Tiotropium Bromide hydrate exerts its biological activity primarily through competitive antagonism at mAChRs resulting in relaxation of airway smooth muscle Based on these pharmacological properties Tiotropium Bromide hydrate holds research potential in respiratory pharmacology particularly for investigating mechanistic pathways in chronic obstructive pulmonary disease (COPD) receptor-ligand interactions and pulmonary pharmacodynamics associated with airway obstruction
Cayman Chemical N4-benzoyl-2-DeoxycytIdIn 10g
A building block; has been used in the synthesis of nucleosides and nucleotides with anticancer activity, as well as oligonucleotides
Apexbio Technology LLC Mepenzolate Bromide 76-90-4 10mM (in 1mL DMSO)
Mepenzolate bromide (CAS 76-90-4) is a synthetic quaternary ammonium compound that functions as a muscarinic acetylcholine receptor antagonist By inhibiting parasympathetic neural transmission it reduces gastric secretion and gastrointestinal motility Mepenzolate bromide is generally supplied as a white to light cream powder with high solubility in methanol limited solubility in water and chloroform and minimal solubility in ether This compound is widely employed in research investigating modulation of cholinergic signaling gastrointestinal physiology and autonomic pharmacology and serves as a tool compound for studying antimuscarinic mechanisms in vitro and in vivo
Medchemexpress LLC Aclidinium Bromide | 320345-99-1 | 98.96% | C26H30BrNO4S2 | 1 ML
Aclidinium Bromide is a long-acting, inhaled muscarinic antagonist with potential for research into chronic obstructive pulmonary disease (COPD). It has shown potent antagonism of human muscarinic receptors preclinically, with a long residence time at M3 receptors, suggesting potential for sustained bronchodilation. Early clinical studies have indicated low systemic bioavailability and a favorable safety profile.
- Long-acting muscarinic antagonist
- Potential for chronic obstructive pulmonary disease (COPD) research
- Exhibits potent antagonism of human muscarinic receptors
- Long residence time at M3 receptors for sustained bronchodilation
- Low systemic bioavailability
- Favorable safety profile
- Rapidly hydrolyzed in human plasma
Medchemexpress LLC 4-(2-Bromoacetyl)benzonitrile | 20099-89-2 | 99.6% | C9H6BrNO | 5 G
4-(2-Bromoacetyl)benzonitrile is a compound that can be used for the synthesis of STA-5312. STA-5312 is a potent and orally active microtubule inhibitor. This product is intended for research use only.
- Solid with an off-white to yellow color
- Can be used for chemical synthesis
- Research use only
Medchemexpress LLC KRN2 bromide | 1390654-28-0 | 98.8% | 524.38 | 1 ML
KRN2 (bromide) is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. It is for research use only and not sold to patients.
- Selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6.
- Dose-dependently inhibits the NF-κB p65 binding to Nfat5 promoter 1.
- Directly blocks the interaction between NF-κB p65 and its DNA binding sequence.
- Effectively suppresses AIA and CIA in mice.
- Decreases the production of pro-inflammatory cytokines and autoantibodies.
- Reduces macrophage infiltration.
Medchemexpress LLC Pinaverium bromide | 53251-94-8 | 99.7% | 591.42 | 10 MG
Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract. It effectively relieves pain, diarrhea, and intestinal discomfort, providing good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients.
- Inhibits GM-CSF or CXCL1/CXCL2 induced neutrophil migration and ROS production.
- Inhibits GM-CSF induced expression of cytokines (IL-1β, IL-6, and TNF-α) in primed neutrophils.
- Inhibits the contractile response to ACh or KCl in colonic circular muscle.
- Inhibits excessive systemic inflammation in Lipopolysaccharide-induced mice.
Medchemexpress LLC N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine | 64325-78-6 | 98.0% | 657.71 | 10 G
N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine can be used as an intermediate. It is for research use only and not sold to patients. The product appears as a white to off-white solid.
- Used as an intermediate.
- Solid appearance.
- White to off-white color.
- Available for research purposes.
AdipoGen Stain 7-I
Chemical. CAS 155862-95-6. Formula C27H22BrN3O6. MW 564.38. Synthetic. New class of highly photostable, water soluble fluorescent labels with large Stokes shift, high QY in aqueous media and pH tolerance.
TARGETMOL CHEMICALS INC Tarloxotinib bromide 1MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2. Purity 97.15%